Comparison Guide
Microsoft Defender vs SentinelOne
Microsoft Defender for Business comes included with Microsoft 365 Business Premium, while SentinelOne is a dedicated endpoint protection platform. The right choice depends on your existing stack and security requirements.
Quick Answer
SentinelOne wins for most buyers.
Depends on existing Microsoft investment and security needs.
Side-by-Side Comparison
| Feature | Microsoft Defender | SentinelOne |
|---|---|---|
| Pricing | Included in M365 Business Premium | Separate per-endpoint cost |
| Autonomous Response | Basic auto-remediation | Advanced autonomous AI response |
| Rollback | Limited | Full ransomware rollback |
| Platform Support | Best on Windows | Windows, Mac, Linux |
| Management Console | Microsoft 365 portal | Dedicated console |
Our Verdict
For businesses already on M365 Business Premium, Defender provides solid baseline protection. SentinelOne offers more advanced autonomous response for organizations needing deeper endpoint security. Either way, we recommend adding MDR (like Huntress) for human-led threat response.
Quick Picks
Which one should you pick?
Three buyer profiles, three answers. Pick the row that fits.
M365 Business Premium shops
Pick: Microsoft Defender
Mostly Windows endpoints and you already pay $22 per user per month for Business Premium, so Defender for Business is in the license you own. Turn it on, tune it, and layer MDR (like Huntress) on top instead of buying a second agent.
Get a Defender deployment quoteMixed-OS or higher-risk fleets
Pick: SentinelOne
Windows, Mac, and Linux under one console, plus autonomous AI response and full ransomware rollback that Defender for Business does not match. Budget roughly $70 to $180 per endpoint per year depending on tier.
Talk to a strategistIn-house IT, licensing and rollout only
Pick: Defender or SentinelOne
Your team runs the console day to day. We size the licensing (Business Premium vs SentinelOne tiers), deploy the agents, set baseline policies, and hand off with documentation so you can self-manage.
Get a licensing and rollout quoteWhy Work With Unio Digital?
We Listen
Personalized, customer-centric culture that puts your needs first.
Customer Focused
You are not just another number. We build lasting partnerships.
Technology That Works
We obsess over vetting solutions and going the extra mile.
Need Help Choosing?
Our team can help you evaluate the right solution for your business. Schedule a free consultation.
Get a Free Quote Contact UsMore Comparisons
Explore other side-by-side comparisons in this category.
Frequently Asked Questions
Learn More About Cybersecurity
Visit our comprehensive Cybersecurity page for detailed information about our capabilities and approach.
Explore Cybersecurity ServicesSources & Methodology
Specifications, pricing, and product capabilities cited on this page are sourced from public vendor documentation as of the dates shown below. Vendor product lines change quickly; verify current specs and pricing directly with each vendor before purchasing.
- Microsoft Defender for Business is included in Microsoft 365 Business Premium ($22.00 per user/month, annual). Bought standalone it lists at $3.00 per user/month (annual). [source] · verified 2026-06-16
- Microsoft Defender for Business standalone supports up to 300 users with up to five devices per user, with no minimum device requirement. [source] · verified 2026-06-16
- Microsoft Defender for Business protects Windows, macOS, iOS, and Android devices; server protection is a separate add-on. [source] · verified 2026-06-16
- SentinelOne Singularity is sold per endpoint per year: Core $69.99, Control $79.99, and Complete $179.99 per endpoint annually, with Commercial at $229.99 and Enterprise priced custom. [source] · verified 2026-06-16
- SentinelOne supports Windows (including legacy EOL versions), macOS, and 13 Linux distributions, plus cloud-native containerized workloads. [source] · verified 2026-06-16