Comparison Guide

Microsoft 365 Copilot vs ChatGPT Enterprise

Microsoft 365 Copilot and ChatGPT Enterprise are the two most-adopted enterprise AI tools, but they solve different problems. Copilot embeds AI inside Microsoft 365 apps your team already uses. ChatGPT Enterprise is a general-purpose assistant accessed through the OpenAI web app and APIs.

Side-by-Side Comparison

Feature Microsoft 365 Copilot ChatGPT Enterprise
Best Ecosystem Fit Microsoft 365 (Outlook, Word, Excel, Teams) Standalone or any productivity stack
Data Residency Microsoft 365 tenant; honors existing permissions OpenAI infrastructure; tenant-scoped, not used for training
In-App Integration Native inside Word, Excel, Outlook, Teams, PowerPoint Web app, mobile, API; not embedded in M365
Custom Agents Copilot Studio agents using M365 data Custom GPTs trained on uploaded documents and APIs
Image Generation Designer integration (DALL-E backend) DALL-E 3 native
Pricing (per user/month) Approximately $30 plus M365 Business plan Approximately $60 (varies by seat count)
Governance Microsoft Purview, sensitivity labels, DLP Admin console with workspace controls
Best For Teams already on M365 wanting embedded AI Teams wanting general-purpose AI plus custom workflows

Our Verdict

If most of your workflow lives in Microsoft 365 (Outlook, Word, Excel, Teams, SharePoint), Microsoft 365 Copilot delivers more value because it works inside the apps. If your team needs general-purpose AI for writing, analysis, coding, and custom workflow automation, ChatGPT Enterprise is the more flexible platform. Most mid-market businesses end up using both, with Copilot for in-app productivity and ChatGPT for general assistance.

Unio Digital recommends: Microsoft 365 Copilot wins for businesses on M365; ChatGPT Enterprise wins for general-purpose AI workloads outside the Microsoft stack

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Frequently Asked Questions

Use Microsoft 365 Copilot if most of your team's work happens inside Outlook, Word, Excel, Teams, and SharePoint. The in-app integration delivers measurable productivity from day one. Use ChatGPT Enterprise if you need a general-purpose AI for writing, analysis, custom GPTs trained on your data, or workflows outside the Microsoft stack. Many mid-market businesses end up running both.

No. OpenAI's Enterprise tier explicitly excludes business prompts from model training. Workspace owners control retention and data export. This is one of the key differences from the consumer ChatGPT Plus tier, which can use prompts for training unless opted out.

Yes. Copilot inherits Microsoft 365 access controls, which means any pre-existing oversharing in SharePoint or OneDrive becomes a Copilot search result on day one. This is why a proper Copilot deployment includes oversharing remediation, sensitivity-label enforcement, and DLP policies before licenses go live.

Learn More About Microsoft Copilot

Visit our comprehensive Microsoft Copilot page for detailed information about our capabilities and approach.

Explore Microsoft Copilot Services